Borrelia miyamotoi: A Comprehensive Review

DW Cleveland, CC Anderson, CA Brissette - Pathogens, 2023 - mdpi.com
Borrelia miyamotoi is an emerging tick-borne pathogen in the Northern Hemisphere and is
the causative agent of Borrelia miyamotoi disease (BMD). Borrelia miyamotoi is vectored by …

[HTML][HTML] Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease–and relapsing fever–causing spirochetes

S Roy, CE Booth, AD Powell-Pierce, AM Schulz… - Journal of Biological …, 2023 - ASBMB
Borrelial pathogens are vector-borne etiological agents known to cause Lyme disease,
relapsing fever, and Borrelia miyamotoi disease. These spirochetes each encode several …

Large-Scale Sequencing of Borreliaceae for the Construction of Pan-Genomic-Based Diagnostics

KM Socarras, BS Haslund-Gourley, NA Cramer… - Genes, 2022 - mdpi.com
The acceleration of climate change has been associated with an alarming increase in the
prevalence and geographic range of tick-borne diseases (TBD), many of which have severe …

Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions

CE Booth Jr, AD Powell-Pierce, JT Skare… - Frontiers in …, 2022 - frontiersin.org
Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host
innate immune system, including the complement cascade. The Lyme disease spirochete …

Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia

LY Mancilla-Agrono, LF Banguero-Micolta… - Tropical medicine and …, 2022 - mdpi.com
The genus Borrelia encompasses spirochetal species that are part of three well-defined
groups. Two of these groups contain pathogens that affect humans: the group causing Lyme …

Analysis of the Borreliaceae Pangenome Reveals a Distinct Genomic Architecture Conserved Across Phylogenetic Scales

JE Lemieux - The Journal of Infectious Diseases, 2024 - academic.oup.com
The family Borreliaceae contains arthropod-borne spirochetes that cause two widespread
human diseases, Lyme disease and relapsing fever. Lyme disease is a subacute …

Experimental transmission of a novel relapsing fever group Borrelia harbored by Ornithodoros octodontus (Ixodida: Argasidae) in Chile

A Santodomingo, R Thomas, M Thompson… - … and Applied Acarology, 2024 - Springer
Tick-borne relapsing fever spirochetes of genus Borrelia thrive in enzootic cycles involving
Ornithodoros spp.(Argasidae) mainly, and rodents. The isolation of these spirochetes …

A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membrane

H He, AS Pramanik, SK Swanson… - Molecular …, 2023 - Wiley Online Library
Borrelia spirochetes are unique among diderm bacteria in their lack of lipopolysaccharide
(LPS) in the outer membrane (OM) and their abundance of surface‐exposed lipoproteins …

Identifying platelet-derived factors as amplifiers of B. burgdorferi-induced cytokine production

M Kerstholt, FR Van de Schoor… - Clinical and …, 2022 - academic.oup.com
Previous studies have shown that monocytes can be 'trained'or tolerized by certain stimuli to
respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was …

Multifunctional interaction of CihC/FbpC orthologs of relapsing fever spirochetes with host-derived proteins involved in adhesion, fibrinolysis, and complement evasion

AS Damm, F Reyer, L Langhoff, YP Lin… - Frontiers in …, 2024 - frontiersin.org
Introduction Relapsing fever (RF) remains a neglected human disease that is caused by a
number of diverse pathogenic Borrelia (B.) species. Characterized by high cell densities in …