Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …

Although our understanding of the involvement of heterochromatin architectural factors in
shaping nuclear organization is improving, there is still ongoing debate regarding the role of …

Metazoan chromosomes are organized into discrete spatial domains (TADs), believed to
contribute to the regulation of transcriptional programs. Despite extensive correlation …

Transcriptional enhancers must find their target genes both efficiently and specifically.
Chromatin conformation capture revealed the critical function of three-dimensional …

Condensins compact chromosomes to promote their equal segregation during mitosis, but
the mechanism of condensin engagement with and action on chromatin is incompletely …

Condensin shapes mitotic chromosomes by folding chromatin into loops, but whether it does
so by DNA-loop extrusion remains speculative. Although loop-extruding cohesin is stalled …

The localization of condensin along chromosomes is crucial for their accurate segregation in
anaphase. Condensin is enriched at telomeres but how and for what purpose had remained …

DNA loop extrusion by SMC proteins is a key process underlying chromosomal
organization. It is unknown how loop extruders interact with telomeres where chromosome …

Metazoan chromosomes are organized into discrete domains (TADs), believed to contribute
to the regulation of transcriptional programs. Despite extensive correlation between TAD …

During mitosis, chromatin is condensed and organized into mitotic chromosomes.
Condensation is critical for genome stability and dynamics, yet the degree of condensation …