Biology and evolution of bacterial toxin–antitoxin systems
Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …
Toxin-antitoxin systems as phage defense elements
Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacteria that consist of a
growth-inhibiting toxin and its cognate antitoxin. These systems are prevalent in bacterial …
growth-inhibiting toxin and its cognate antitoxin. These systems are prevalent in bacterial …
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
N Đukić, Ø Strømland, JD Elsborg, D Munnur, K Zhu… - Science …, 2023 - science.org
PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …
transcription, and DNA replication stress management. However, little is known about the …
[HTML][HTML] ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA
Toxin-antitoxin (TA) systems are broadly distributed, yet poorly conserved, genetic elements
whose biological functions are unclear and controversial. Some TA systems may provide …
whose biological functions are unclear and controversial. Some TA systems may provide …
[HTML][HTML] Toxins, targets, and triggers: an overview of toxin-antitoxin biology
Bacterial toxin-antitoxin (TA) modules are abundant genetic elements that encode a toxin
protein capable of inhibiting cell growth and an antitoxin that counteracts the toxin. The …
protein capable of inhibiting cell growth and an antitoxin that counteracts the toxin. The …
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
The comings and goings of PARP-1 in response to DNA damage
JM Pascal - DNA repair, 2018 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
Insights into the biogenesis, function, and regulation of ADP-ribosylation
MS Cohen, P Chang - Nature chemical biology, 2018 - nature.com
ADP-ribosylation—the transfer of ADP-ribose (ADPr) from NAD+ onto target molecules—is
catalyzed by members of the ADP-ribosyltransferase (ART) superfamily of proteins, found in …
catalyzed by members of the ADP-ribosyltransferase (ART) superfamily of proteins, found in …
ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …