Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility
Well-authenticated biomarkers can provide critical insights into the biological basis of
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …
[HTML][HTML] Parkinson disease-associated cognitive impairment
Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting>
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
Background Given the projected trends in population ageing and population growth, the
number of people with dementia is expected to increase. In addition, strong evidence has …
number of people with dementia is expected to increase. In addition, strong evidence has …
The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017
G Deuschl, E Beghi, F Fazekas, T Varga… - The Lancet Public …, 2020 - thelancet.com
Background Neurological disorders account for a large and increasing health burden
worldwide, as shown in the Global Burden of Diseases (GBD) Study 2016. Unpacking how …
worldwide, as shown in the Global Burden of Diseases (GBD) Study 2016. Unpacking how …
Global prevalence of young-onset dementia: a systematic review and meta-analysis
S Hendriks, K Peetoom, C Bakker… - JAMA …, 2021 - jamanetwork.com
Importance Reliable prevalence estimates are lacking for young-onset dementia (YOD), in
which symptoms of dementia start before the age of 65 years. Such estimates are needed for …
which symptoms of dementia start before the age of 65 years. Such estimates are needed for …
Therapeutic approach to Alzheimer's disease: current treatments and new perspectives
T Pardo-Moreno, A González-Acedo… - Pharmaceutics, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. The pathophysiology of
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …
Current and future treatments in Alzheimer disease: an update
KG Yiannopoulou… - Journal of central …, 2020 - journals.sagepub.com
Disease-modifying treatment strategies for Alzheimer disease (AD) are still under extensive
research. Nowadays, only symptomatic treatments exist for this disease, all trying to …
research. Nowadays, only symptomatic treatments exist for this disease, all trying to …
Dementia in China: epidemiology, clinical management, and research advances
L Jia, M Quan, Y Fu, T Zhao, Y Li, C Wei… - The Lancet …, 2020 - thelancet.com
China has the largest population of patients with dementia in the world, imposing a heavy
burden on the public and health care systems. More than 100 epidemiological studies on …
burden on the public and health care systems. More than 100 epidemiological studies on …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial
JD Williamson, NM Pajewski, AP Auchus, RN Bryan… - Jama, 2019 - jamanetwork.com
Importance There are currently no proven treatments to reduce the risk of mild cognitive
impairment and dementia. Objective To evaluate the effect of intensive blood pressure …
impairment and dementia. Objective To evaluate the effect of intensive blood pressure …