Exploring the multi-faceted role of sirtuins in glioblastoma pathogenesis and targeting options
E Kunadis, C Piperi - International Journal of Molecular Sciences, 2022 - mdpi.com
Recent advances in glioblastoma (GB) research have shed light on the molecular
characteristics, the defected intracellular signaling pathways, and the genetic and epigenetic …
characteristics, the defected intracellular signaling pathways, and the genetic and epigenetic …
Effect of Extent of Resection on Survival of Patients with Glioblastoma, IDH–Wild-Type, WHO Grade 4 (WHO 2021): Systematic Review and Meta-Analysis
Background In light of the recently updated World Health Organization (WHO) 2021 central
nervous system tumor classifications, the aim of the present study was to establish the effect …
nervous system tumor classifications, the aim of the present study was to establish the effect …
Clinical updates on gliomas and implications of the 5th edition of the WHO classification of central nervous system tumors
X Guo, Y Shi, D Liu, Y Li, W Chen, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Background The 5th edition of the World Health Organization (WHO) classification of central
nervous system tumors incorporated specific molecular alterations into the categorization of …
nervous system tumors incorporated specific molecular alterations into the categorization of …
A Novel Type of IDH-wildtype Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile
A Muench, D Teichmann, D Spille… - The American Journal …, 2023 - journals.lww.com
Diffuse gliomas in adults encompass a heterogenous group of central nervous system
neoplasms. In recent years, extensive (epi-) genomic profiling has identified several glioma …
neoplasms. In recent years, extensive (epi-) genomic profiling has identified several glioma …
Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and …
FFV Silva, M Di Domenico, VCA Caponio… - International Journal of …, 2024 - mdpi.com
The O-6-methylguanine-DNA methyltransferase (MGMT) gene is a critical guardian of
genomic integrity. MGMT methylation in diffuse gliomas serves as an important determinant …
genomic integrity. MGMT methylation in diffuse gliomas serves as an important determinant …
Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone
ES Norton, LA Whaley, VK Jones, MM Brooks… - Science …, 2024 - science.org
Glioblastoma (GBM) is the most prevalent and aggressive malignant primary brain tumor.
GBM proximal to the lateral ventricles (LVs) is more aggressive, potentially because of …
GBM proximal to the lateral ventricles (LVs) is more aggressive, potentially because of …
IDH wild-type lower-grade gliomas with glioblastoma molecular features: A systematic review and meta-analysis
S Nakasu, S Deguchi, Y Nakasu - Brain Tumor Pathology, 2023 - Springer
The WHO 2021 classification defines IDH wild type (IDHw) histologically lower-grade glioma
(hLGG) as molecular glioblastoma (mGBM) if TERT promoter mutation (pTERTm), EGFR …
(hLGG) as molecular glioblastoma (mGBM) if TERT promoter mutation (pTERTm), EGFR …
Chromosomal instability: a key driver in glioma pathogenesis and progression
Chromosomal instability (CIN) is a pivotal factor in gliomas, contributing to their complexity,
progression, and therapeutic challenges. CIN, characterized by frequent genomic alterations …
progression, and therapeutic challenges. CIN, characterized by frequent genomic alterations …
Histological and molecular glioblastoma, IDH-wildtype: a real-world landscape using the 2021 WHO classification of central nervous system tumors
X Guo, L Gu, Y Li, Z Zheng, W Chen, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Introduction Glioblastoma (GBM), the most lethal primary brain malignancy, is divided into
histological (hist-GBM) and molecular (mol-GBM) subtypes according to the 2021 World …
histological (hist-GBM) and molecular (mol-GBM) subtypes according to the 2021 World …
Diffusion tensor imaging‐based machine learning for IDH wild‐type glioblastoma stratification to reveal the biological underpinning of radiomic features
Z Wang, F Guan, W Duan, Y Guo, D Pei… - CNS Neuroscience …, 2023 - Wiley Online Library
Introduction This study addresses the lack of systematic investigation into the prognostic
value of hand‐crafted radiomic features derived from diffusion tensor imaging (DTI) in …
value of hand‐crafted radiomic features derived from diffusion tensor imaging (DTI) in …