Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

C Liao, X Huang, Q Wang, D Yao, W Lu - Frontiers in cellular and …, 2022 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in
severely ill and immunocompromised patients. Ubiquitously disseminated in the …

Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection

CS Curran, T Bolig, P Torabi-Parizi - American journal of respiratory …, 2018 - atsjournals.org
Pseudomonas aeruginosa is a complex gram-negative facultative anaerobe replete with a
variety of arsenals to activate, modify, and destroy host defense mechanisms. The microbe is …

Molecular Characterization and Designing of a Novel Multiepitope Vaccine Construct Against Pseudomonas aeruginosa

J Dey, SR Mahapatra, S Patnaik, S Lata… - International Journal of …, 2022 - Springer
Pseudomonas aeruginosa, an ESKAPE pathogen causes many fatal clinical diseases in
humans across the globe. Despite an increase in clinical instances of Pseudomonas …

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

M Sainz-Mejías, I Jurado-Martín, S McClean - Cells, 2020 - mdpi.com
Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

X Wang, C Liu, N Rcheulishvili, D Papukashvili, F Xie… - npj Vaccines, 2023 - nature.com
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-
associated pneumonia. The multidrug-resistance (MDR) rate of PA is increasing making the …

[HTML][HTML] Pseudomonas aeruginosa: Infections and novel approaches to treatment “Knowing the enemy” the threat of Pseudomonas aeruginosa and exploring novel …

N Sathe, P Beech, L Croft, C Suphioglu, A Kapat… - Infectious Medicine, 2023 - Elsevier
Pseudomonas aeruginosa is an aerobic Gram-negative rod-shaped bacterium with a
comparatively large genome and an impressive genetic capability allowing it to grow in a …

Progress Toward the Elusive Pseudomonas aeruginosa Vaccine

C Merakou, MM Schaefers, GP Priebe - Surgical infections, 2018 - liebertpub.com
Background: The gram-negative bacterial pathogen Pseudomonas aeruginosa causes a
wide range of infections, mostly in hospitalized and immunocompromised patients, those …

Multidrug efflux pumps and the two-faced janus of substrates and inhibitors

HI Zgurskaya, JK Walker, JM Parks… - Accounts of chemical …, 2021 - ACS Publications
Conspectus Antibiotics are miracle drugs that can cure infectious bacterial diseases.
However, their utility is challenged by antibiotic-resistant bacteria emerging in clinics and …

Bacteriophage therapy increases complement-mediated lysis of bacteria and enhances bacterial clearance after acute lung infection with multidrug-resistant …

AM Abd El-Aziz, A Elgaml, YM Ali - The Journal of Infectious …, 2019 - academic.oup.com
Emergence of multidrug-resistant (MDR) bacterial infections is a major problem in clinical
medicine. Development of new strategies such as phage therapy may be a novel approach …

Vaccines for multidrug resistant Gram negative bacteria: Lessons from the past for guiding future success

M Lopez-Siles, A Corral-Lugo… - FEMS microbiology …, 2021 - academic.oup.com
Antimicrobial resistance is a major threat to global public health. Vaccination is an effective
approach for preventing bacterial infections, however it has not been successfully applied to …