Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a
marked impact on the wellbeing and productivity of individuals and has a major economic …

The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …

Upon oxidative stress and aging, Nrf2 (NFE2-related factor2) triggers antioxidant defense
genes to defends against homeostatic failure. Using human (h) or rat (r) lens epithelial cells …

The eye lens is constantly subjected to oxidative stress from radiation and other sources.
The lens has several mechanisms to protect its components from oxidative stress and to …

Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to
balance cellular hydrogen peroxide (H 2 O 2) levels, which are essential for cell signaling …

Ferroptosis is a newly characterized iron-dependent form of nonapoptotic regulated cell
death triggered by lipid reactive oxygen species (LOOH). The dysregulation of ferroptosis is …

Patients with acute lung injury develop hypoxia, which may lead to lung dysfunction and
aberrant tissue repair. Recent studies have suggested that epithelial-mesenchymal …

Sigma-1 receptors are associated with Alzheimer's disease, major depressive disorders,
and schizophrenia. These receptors show progrowth/antiapoptotic properties via their …

Many disorders of aging, including blinding-diseases, are associated with deficiency of brain
and muscle arnt-like protein 1 (Bmal1) and, thereby, dysregulation of antioxidant-defense …

Transforming growth factor-β s (TGF-β) regulate a wide variety of cellular functions in normal
development and are involved in both tissue homeostasis and disease pathogenesis. The …