The role of cytochrome P450s in insect toxicology and resistance

R Nauen, C Bass, R Feyereisen… - Annual Review of …, 2022 - annualreviews.org
Insect cytochrome P450 monooxygenases (P450s) perform a variety of important
physiological functions, but it is their role in the detoxification of xenobiotics, such as natural …

The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics

K Lu, Y Song, R Zeng - Current Opinion in Insect Science, 2021 - Elsevier
Insect cytochrome P450 monooxygenases (P450s) are well known to be involved in
metabolic detoxification of xenobiotics, such as phytochemicals, insecticides and …

Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens, a natural waste recycler

S Zhan, G Fang, M Cai, Z Kou, J Xu, Y Cao, L Bai… - Cell research, 2020 - nature.com
The black soldier fly (BSF), Hermetia illucens (Diptera: Stratiomyidae), is renowned for its
bioconversion of organic waste into a sustainable source of animal feed. We report a high …

Insecticide resistance and management strategies in urban ecosystems

F Zhu, L Lavine, S O'Neal, M Lavine, C Foss, D Walsh - Insects, 2016 - mdpi.com
The increased urbanization of a growing global population makes imperative the
development of sustainable integrated pest management (IPM) strategies for urban pest …

Contribution of multiple overexpressed carboxylesterase genes to indoxacarb resistance in Spodoptera litura

Y Shi, W Li, Y Zhou, X Liao, L Shi - Pest management science, 2022 - Wiley Online Library
BACKGROUND As an important family of detoxification enzymes, carboxylesterases (CarEs)
have important roles in the development of insecticide resistance in almost all agricultural …

An overview of the main pathways of metabolic resistance in insects

M Panini, GC Manicardi, GD Moores… - Invertebrate Survival …, 2016 - isj.unimore.it
Insecticides have played and still fulfil a very important role in sustainable production of
food, animal feed and also as protection against disease vectors. They act to suppress …

G-protein coupled receptors (GPCRs): signaling pathways, characterization, and functions in insect physiology and toxicology

N Liu, Y Wang, T Li, X Feng - International Journal of Molecular Sciences, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are known to play central roles in the physiology of
many organisms. Members of this seven α-helical transmembrane protein family transduce …

Comprehensive analysis of the overexpressed cytochrome P450-based insecticide resistance mechanism in Spodoptera litura

W Li, W Yang, Y Shi, X Yang, S Liu, X Liao… - Journal of Hazardous …, 2024 - Elsevier
Cytochrome P450s play critical roles in the metabolic resistance of insecticides in insects.
Previous findings showed that enhanced P450 activity was an important mechanism …

Metabolic imidacloprid resistance in the brown planthopper, Nilaparvata lugens, relies on multiple P450 enzymes

Y Zhang, Y Yang, H Sun, Z Liu - Insect biochemistry and molecular biology, 2016 - Elsevier
Target insensitivity contributing to imidacloprid resistance in Nilaparvata lugens has been
reported to occur either through point mutations or quantitative change in nicotinic …

The role of insect cytochrome P450s in mediating insecticide resistance

M Ye, B Nayak, L Xiong, C Xie, Y Dong, M You, Z Yuchi… - Agriculture, 2022 - mdpi.com
In many organisms, cytochrome P450 enzymes are the primary detoxifying enzymes.
Enhanced P450 activity can be mediated by the emergence of new genes, increased …