▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Inhibition of the nuclear export of poly (A)-containing mRNAs caused by the influenza A virus
NS1 protein requires its effector domain. Here, we demonstrate that the NS1 effector domain …

Active transport between the nucleus and cytoplasm involves primarily three classes of
macromolecules: substrates, adaptors, and receptors. Some transport substrates bind …

Failure of clinical trials of nonviral vector-mediated gene therapy arises primarily from either
an insufficient transgene expression level or immunostimulation concerns caused by the …

Results The Binding Specificity of the Cap Recognition Factor Involved in-Pre-mRNA
Splicing It has previously been shown that recognition of the cap structure plays an …

Influenza A virus NS1 protein (NS1A protein) via its effector domain targets the poly (A)‐
binding protein II (PABII) of the cellular 3′‐end processing machinery. In vitro the NS1A …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …

In higher eukaryotes, intron-containing and intronless versions of otherwise identical genes
can exhibit dramatically different expression profiles. Introns and the act of their removal by …

Poly (A) tails are found at the 3′ ends of almost all eukaryotic mRNAs. They are bound by
two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus …