M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds

Y Wang, W Smith, D Hao, B He, L Kong - International …, 2019 - Elsevier
Macrophages, as crucial cellular components of innate immunity, are characterized by
possessing high plasticity and an abnormal ability to differentiate in response to numerous …

The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration

F De Santa, L Vitiello, A Torcinaro… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Macrophages are crucial for tissue homeostasis. Based on their activation,
they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro …

The role of Omega-3 polyunsaturated fatty acids and their lipid mediators on skeletal muscle regeneration: a narrative review

S Jannas-Vela, A Espinosa, AA Candia… - Nutrients, 2023 - mdpi.com
Skeletal muscle is the largest tissue in the human body, comprising approximately 40% of
body mass. After damage or injury, a healthy skeletal muscle is often fully regenerated; …

[HTML][HTML] A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis

Y Yuan, Z Zhang, F Mo, C Yang, Y Jiao, E Wang… - Bioactive Materials, 2023 - Elsevier
Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb
ischemic diseases. In this study, a triple-functional Sr/Si-containing bioceramic/alginate …

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

PP Laurila, P Luan, M Wohlwend, N Zanou, B Crisol… - Science …, 2022 - science.org
Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe
muscle disorder, causing muscle weakness, loss of independence, and premature death …

Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments

E Espino-Gonzalez, E Dalbram, R Mounier, J Gondin… - Cell Metabolism, 2024 - cell.com
Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

Skeletal muscle metabolism in duchenne and becker muscular dystrophy—Implications for therapies

A Heydemann - Nutrients, 2018 - mdpi.com
The interactions between nutrition and metabolism and skeletal muscle have long been
known. Muscle is the major metabolic organ—it consumes more calories than other organs …

Eicosapentaenoic acid enhances the effects of mesenchymal stromal cell therapy in experimental allergic asthma

SC Abreu, M Lopes-Pacheco, AL Da Silva… - Frontiers in …, 2018 - frontiersin.org
Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness.
Despite recent advances in the understanding of its pathophysiology, asthma remains a …

Long‐term administration of eicosapentaenoic acid improves post–myocardial infarction cardiac remodeling in mice by regulating macrophage polarization

M Takamura, K Kurokawa, H Ootsuji… - Journal of the …, 2017 - Am Heart Assoc
Background Consumption of n‐3 fatty acids reduces the incidence of cardiovascular
mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an …

Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes

M Liu, M Ng, T Phu, L Bouchareychas… - Stem Cell Research & …, 2023 - Springer
Background Macrophage polarization has been observed in the process of muscle injuries
including rotator cuff (RC) muscle atrophy and fatty infiltration after large tendon tears. In our …