Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

This review introduces the pathology of aminoglycoside antibiotic and the cisplatin
chemotherapy classes of drugs, discusses oxidative stress in the inner ear as a primary …

Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a
result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological …

Abstract The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the
large TRP family of ion channels, and functions as a Ca 2+ permeable non-selective cation …

Ototoxicity refers to damage of inner ear structures (ie, the cochlea and vestibule) and their
function (hearing and balance) following exposure to specific in-hospital medications (ie …

The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing
neurons and other tissues and has become a major target in the development of novel …

Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect
termination of translation and generation of non-functional, truncated proteins. Translational …

Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the
irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then …

Purpose This review article summarizes our current understanding of the mechanisms
underlying acquired hearing loss from hospital-prescribed medications that affects as many …

The Ototoxicity Working Group of Pharmaceutical Interventions for Hearing Loss defined
ototoxicity as damage to the inner ear, targeting cochlear and vestibular structures as well as …