The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …

Mitochondria are the energy factories of the cell and also serve as a checkpoint regulating
programmed cell death. Not surprisingly, dysfunctional mitochondria are implicated in a …

Peptide nucleic acid (PNA) is a DNA mimic having a pseudopeptide backbone that makes it
extremely stable in biological fluids. PNA binds complementary RNA and DNA with high …

In recent years, a new generation of drugs has entered the pharmaceutical market. Some
are more potent, but some are also more toxic and thus, therapeutical efficacy may be …

Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide
backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]) …

Mitochondrial disorders are an important group of genetic conditions characterized by
impaired oxidative phosphorylation. Mitochondrial disorders come with an impressive …

Mitochondria-targeted molecules comprising the lipophilic TPP (triphenylphosphonium)
cation covalently linked to a hydrophobic bioactive moiety are used to modify and probe …

Plant mitochondria are remarkable with respect to their content in foreign, alien and plasmid‐
like DNA, raising the question of the transfer of this information into the organelles. We …

Peptides and analogs such as peptide nucleic acids (PNA) are promising tools and
therapeutics, but the cell membrane remains a barrier to intracellular targets. Conjugation to …