Central nervous system tumors comprising the primary cancers and brain metastases
remain the most lethal neoplasms and challenging to treat. Substantial evidence points to a …

Background The use of temozolomide (TMZ) has improved the prognosis for glioblastoma
multiforme patients. However, TMZ resistance may be one of the main reasons why …

Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but
its role in the clinical management of diffuse low-grade gliomas (LGG) is still being defined …

The study of genetic polymorphisms has significantly advanced the field of personalized
medicine. Polymorphism of genes influence the efficacy of drugs used for treating medical …

Aim: Assess differential patterns of selected five genes' promoter methylation among
testicular germ cell tumors (TGCT) subtypes. Materials & methods: CRIPTO, HOXA9, MGMT …

Background Colorectal cancer (CRC) is one of the most incident cancers, associated with
significant morbidity and mortality, and usually classified into three main molecular …

Clinical and molecular prognostic factors in gliomas include age, IDH mutation, the glioma
CpG island methylator phenotype (G-CIMP+) and promoter methylation of the O 6 …

The methylation status of the promoter of MGMT gene is a crucial factor influencing clinical
decision-making in patients with gliomas. MGMT pyrosequencing results are often …

Apart from genetic mutations, epigenetic alteration is a common phenomenon that
contributes to neoplastic transformation in colorectal cancer. Transcriptional silencing of …

Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …