Pivotal mental states

A Brouwer, RL Carhart-Harris - Journal of …, 2021 - journals.sagepub.com
This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders

AJ Murray, JC Rogers, MZUH Katshu, PF Liddle… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

D De Gregorio, J Popic, JP Enns, A Inserra… - Proceedings of the …, 2021 - pnas.org
Clinical studies have reported that the psychedelic lysergic acid diethylamide (LSD)
enhances empathy and social behavior (SB) in humans, but its mechanism of action …

The interplay between the endocannabinoid system, epilepsy and cannabinoids

KA Kwan Cheung, H Peiris, G Wallace… - International journal of …, 2019 - mdpi.com
Epilepsy is a neurological disorder that affects approximately 50 million people worldwide.
There is currently no definitive epilepsy cure. However, in recent years, medicinal cannabis …

[HTML][HTML] Impact of neuroimmune activation induced by alcohol or drug abuse on adolescent brain development

C Guerri, M Pascual - International Journal of Developmental Neuroscience, 2019 - Elsevier
Evidence obtained in recent decades has demonstrated that the brain still matures in
adolescence. Changes in neural connectivity occur in different regions, including cortical …

CIBERSAM: Ten years of collaborative translational research in mental disorders

E Salagre, C Arango, F Artigas… - … de Psiquiatria y …, 2019 - pubmed.ncbi.nlm.nih.gov
CIBERSAM: Ten years of collaborative translational research in mental disorders CIBERSAM:
Ten years of collaborative translational research in mental disorders Rev Psiquiatr Salud Ment …

Phytocannabinoids and schizophrenia: Focus on adolescence as a critical window of enhanced vulnerability and opportunity for treatment

T Stark, S Di Martino, F Drago, CT Wotjak… - Pharmacological …, 2021 - Elsevier
The recent shift in socio-political debates and growing liberalization of Cannabis use across
the globe has raised concern regarding its impact on vulnerable populations such as …

Cannabidiol and neurodevelopmental disorders in children

KA Kwan Cheung, MD Mitchell, HS Heussler - Frontiers in Psychiatry, 2021 - frontiersin.org
Neurodevelopmental and neuropsychiatric disorders (such as autism spectrum disorder)
have broad health implications for children, with no definitive cure for the vast majority of …

Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients

I Ibarra‐Lecue, P Unzueta‐Larrinaga… - Addiction …, 2022 - Wiley Online Library
Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an
earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5‐HT2AR) …

[HTML][HTML] Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1 …

A García-Bea, P Miranda-Azpiazu, C Muguruza… - European …, 2019 - Elsevier
Abstract Serotonin 5-HT 2A receptors (5-HT 2A Rs) have been implicated in schizophrenia.
However, postmortem studies on 5-HT 2A Rs expression and functionality in schizophrenia …