The metabolic stability of the nicotinic acetylcholine receptor at the neuromuscular junction

I Martinez-Pena y Valenzuela, M Akaaboune - Cells, 2021 - mdpi.com
The clustering and maintenance of nicotinic acetylcholine receptors (AChRs) at high density
in the postsynaptic membrane is a hallmark of the mammalian neuromuscular junction …

Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation

SG Cook, AM Bourke, H O'Leary, V Zaegel, E Lasda… - Scientific reports, 2018 - nature.com
Four CaMKII isoforms are encoded by distinct genes, and alternative splicing within the
variable linker-region generates additional diversity. The α and β isoforms are largely brain …

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

S Herranz-Martin, J Chandran… - Disease models & …, 2017 - journals.biologists.com
Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major …

AChRs are essential for the targeting of rapsyn to the postsynaptic membrane of NMJs in living mice

PJ Chen, IMP y Valenzuela, M Aittaleb… - Journal of …, 2016 - Soc Neuroscience
Rapsyn, a 43 kDa scaffold protein, is required for the clustering of acetylcholine receptors
(AChRs) at synaptic sites between mammalian motor neurons and muscle cells. However …

Distinct roles of the dystrophin–glycoprotein complex: α-dystrobrevin and α-syntrophin in the maintenance of the postsynaptic apparatus of the neuromuscular …

IMP Valenzuela, PJ Chen, J Barden… - Human Molecular …, 2022 - academic.oup.com
Abstract α-syntrophin (α-syn) and α-dystrobrevin (α-dbn), two components of the dystrophin–
glycoprotein complex, are essential for the maturation and maintenance of the …

[HTML][HTML] The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice

IMP y Valenzuela, M Akaaboune - Molecular metabolism, 2020 - Elsevier
Objective A sustained high fat diet in mice mimics many features of human obesity. We used
male and female Non-Swiss albino mice to investigate the impact of short and long-term …

[HTML][HTML] The metabolic stability of the nicotinic acetylcholine receptor at the neuromuscular junction

IMP y Valenzuela, M Akaaboune - Cells, 2021 - ncbi.nlm.nih.gov
The clustering and maintenance of nicotinic acetylcholine receptors (AChRs) at high density
in the postsynaptic membrane is a hallmark of the mammalian neuromuscular junction …

Deletion of Pofut1 in mouse skeletal myofibers induces muscle aging-related phenotypes in cis and in trans

DA Zygmunt, N Singhal, ML Kim… - … and Cellular Biology, 2017 - journals.asm.org
Sarcopenia, the loss of muscle mass and strength during normal aging, involves coordinate
changes in skeletal myofibers and the cells that contact them, including satellite cells and …

Spatial distribution and molecular dynamics of dystrophin glycoprotein components at the neuromuscular junction in vivo

M Aittaleb, I Martinez-Pena y Valenzuela… - Journal of cell …, 2017 - journals.biologists.com
ABSTRACT A bimolecular fluorescence complementation (BiFC) approach was used to
study the molecular interactions between different components of the postsynaptic protein …

Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability

PJ Chen, D Zelada, DC Belhasan… - Journal of Biological …, 2020 - ASBMB
The maintenance of a high density of the acetylcholine receptor (AChR) is the hallmark of
the neuromuscular junction. Muscle-specific anchoring protein (αkap) encoded within the …