Therapeutic advances of rare ALK fusions in non-small cell lung cancer
Y Xiang, S Zhang, X Fang, Y Jiang, T Fang, J Liu… - Current Oncology, 2022 - mdpi.com
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer
cases and is the leading cause of cancer-related death. Despite advances in chemotherapy …
cases and is the leading cause of cancer-related death. Despite advances in chemotherapy …
ALK in Non-Small Cell Lung Cancer (NSCLC) Pathobiology, Epidemiology, Detection from Tumor Tissue and Algorithm Diagnosis in a Daily Practice
P Hofman - Cancers, 2017 - mdpi.com
Patients with advanced-stage non-small cell lung carcinoma (NSCLC) harboring an ALK
rearrangement, detected from a tissue sample, can benefit from targeted ALK inhibitor …
rearrangement, detected from a tissue sample, can benefit from targeted ALK inhibitor …
Comparison of ALK detection by FISH, IHC and NGS to predict benefit from crizotinib in advanced non-small-cell lung cancer
C Lin, X Shi, S Yang, J Zhao, Q He, Y Jin, X Yu - Lung Cancer, 2019 - Elsevier
Purpose Anaplastic lymphoma kinase (ALK) is now a validated kinase target in non-small
cell lung cancer (NSCLC). We implemented three ALK laboratory methodologies …
cell lung cancer (NSCLC). We implemented three ALK laboratory methodologies …
[HTML][HTML] Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches
JA Vendrell, S Taviaux, B Béganton, S Godreuil… - Scientific reports, 2017 - nature.com
Rearrangements of the anaplastic lymphoma kinase (ALK) gene in non-small cell lung
cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although …
cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although …
Clinical utility and performance of an ultrarapid multiplex RNA-based assay for detection of ALK, ROS1, RET, and NTRK1/2/3 rearrangements and MET exon 14 …
Several kinase fusions are established targetable drivers in lung cancers. However, rapid
and comprehensive detection remains challenging because of diverse partner genes and …
and comprehensive detection remains challenging because of diverse partner genes and …
Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS …
LF Leal, FE De Paula, P De Marchi… - Scientific reports, 2019 - nature.com
Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and
KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The …
KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The …
SPP1 overexpression is associated with poor outcomes in ALK fusion lung cancer patients without receiving targeted therapy
X Ji, Y Liu, F Mei, X Li, M Zhang, B Yao, R Wu, J You… - Scientific reports, 2021 - nature.com
The screening of non-small cell lung cancer (NSCLC) tumors for anaplastic lymphoma
receptor tyrosine kinase (ALK) gene rearrangements is important because of the …
receptor tyrosine kinase (ALK) gene rearrangements is important because of the …
[HTML][HTML] Gene expression profiles (Geps) of immuno-oncologic pathways as predictors of response to checkpoint inhibitors in advanced nsclc
P De Marchi, LF Leal, LS da Silva… - Translational …, 2024 - Elsevier
Abstract Background Immune checkpoint inhibitors (ICIs) revolutionized non-small-cell lung
cancer (NSCLC) treatment. However, improving patients' selection for this therapy is …
cancer (NSCLC) treatment. However, improving patients' selection for this therapy is …
[HTML][HTML] Diagnostic utility of gene fusion panel to detect gene fusions in fresh and formalin-fixed, paraffin-embedded cancer specimens
L Haley, V Parimi, L Jiang, A Pallavajjala… - The Journal of Molecular …, 2021 - Elsevier
Somatic gene fusions are common in leukemias/lymphomas and solid tumors. The detection
of gene fusions is crucial for diagnosis. NanoString fusion technology is a multiplexed …
of gene fusions is crucial for diagnosis. NanoString fusion technology is a multiplexed …
Detection of NTRK fusions by RNA-based nCounter is a feasible diagnostic methodology in a real-world scenario for non-small cell lung cancer assessment
R de Oliveira Cavagna, ES de Andrade… - Scientific Reports, 2023 - nature.com
Abstract NTRK1, 2, and 3 fusions are important therapeutic targets for NSCLC patients, but
their prevalence in South American admixed populations needs to be better explored. NTRK …
their prevalence in South American admixed populations needs to be better explored. NTRK …