Though hundreds of drugs have been approved by the US Food and Drug Administration
(FDA) for treating various rare diseases, most rare diseases still lack FDA-approved …

Phase I oncology clinical trials often comprise a limited number of patients representing
different disease subtypes who are divided into cohorts receiving treatment (s) at different …

Quantitative systems pharmacology (QSP) places an emphasis on dynamic systems
modeling, incorporating considerations from systems biology modeling and …

Advances in biomedical and computer technologies have presented the modeling
community the opportunity for mechanistically modeling and simulating the variability in a …

As decisions in drug development increasingly rely on predictions from mechanistic systems
models, assessing the predictive capability of such models is becoming more important …

Despite recent progress in adoptive T cell therapy for cancer, understanding and predicting
the kinetics of infused T cells remains a challenge. Multiple factors can impact the …

Abstract Quantitative Systems Pharmacology (QSP) has emerged as a powerful ensemble of
approaches aiming at developing integrated mathematical and computational models …

Asthma is a complex, heterogeneous disease with a high unmet medical need, despite
therapies targeting a multitude of pathways. The ability to quantitatively integrate preclinical …

Background and Purpose RO7502175 is an afucosylated antibody designed to eliminate C–
C motif chemokine receptor 8 (CCR8)+ Treg cells in the tumour microenvironment through …

Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disease that affects about
0.1% to 2% of the population worldwide. Despite the development of several novel …