Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification

B Meeusen, V Janssens - The international journal of biochemistry & cell …, 2018 - Elsevier
Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Mechanisms of osteoblastic bone metastasis in prostate cancer: role of prostatic acid phosphatase

M Quiroz-Munoz, S Izadmehr… - Journal of the …, 2019 - academic.oup.com
Prostate cancer (PCa) preferentially metastasizes to bone, leading to complications
including severe pain, fractures, spinal cord compression, bone marrow suppression, and a …

[HTML][HTML] Convergent network effects along the axis of gene expression during prostate cancer progression

K Charmpi, T Guo, Q Zhong, U Wagner, R Sun… - Genome Biology, 2020 - Springer
Background Tumor-specific genomic aberrations are routinely determined by high-
throughput genomic measurements. It remains unclear how complex genome alterations …

[HTML][HTML] The role of snapin in regulation of brain homeostasis

J Li, X Huang, Y An, X Chen, Y Chen… - Neural Regeneration …, 2024 - journals.lww.com
Brain homeostasis refers to the normal working state of the brain in a certain period, which is
important for overall health and normal life activities. Currently, there is a lack of effective …

Snapin 蛋白在调节脑稳态中的作用

J Li, X Huang, Y An, X Chen, Y Chen, M Xu… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
脑稳态是指大脑在一定时间内的正常工作状态, 对于人体的健康和正常生命活动具有重要意义.
目前针对脑稳态失调所带来的不良后果, 尚缺乏有效的治疗方法. 近期, 许多研究人员报道snapin …

[HTML][HTML] Transmembrane prostatic acid phosphatase: a therapeutic target in advanced prostate cancer

A Kirschenbaum, P Cheung… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Prostate cancer (PCa) is the most common cancer and second leading cause of cancer
death in American men. Most patients with metastatic disease respond initially to androgen …

A new oxopiperazin‐based peptidomimetic molecule inhibits prostatic acid phosphatase secretion and induces prostate cancer cell apoptosis

P Zer Aviv, M Shubely, Y Moskovits, O Viskind… - …, 2016 - Wiley Online Library
Abstract Reduced Prostatic acid Phosphatase (PAcP) secretion is associated with inhibition
of the proliferation rate of prostate cancer cells. Signal peptidase 1 (SPase 1) is the main …

Proteogenomic heterogeneity of localized human prostate cancer progression

K Charmpi, T Guo, Q Zhong, U Wagner, R Sun… - bioRxiv, 2020 - biorxiv.org
Tumor-specific genomic aberrations are routinely determined by high throughput genomic
measurements. However, it is unclear how complex genome alterations affect molecular …