Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …

Chaperonins are intricate allosteric machines formed of two back-to-back, stacked rings of
subunits presenting end cavities lined with hydrophobic binding sites for nonnative …

Aneuploidy—the state of having uneven numbers of chromosomes—is a hallmark of cancer
and a feature identified in yeast from diverse habitats,,,. Recent studies have shown that …

In this Opinion article, we aim to address how cells adapt to stress and the repercussions
chronic stress has on cellular function. We consider acute and chronic stress-induced …

Hsp90 is a ubiquitous and essential molecular chaperone that plays central roles in many
signaling and other cellular pathways. The in vivo and in vitro activity of Hsp90 depends on …

Successful completion of mitosis requires that sister kinetochores become attached end-on
to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming …

Plant hormones play pivotal roles in growth, development and stress responses. Although it
is essential to our understanding of hormone signalling, how plants maintain a steady state …

Accurate chromosome segregation requires assembly of the multiprotein kinetochore
complex. Prior work has identified more than 100 different kinetochore components in …

The autoregulatory loops of the circadian clock consist of feedback regulation of
transcription/translation circuits but also require finely coordinated cytoplasmic and nuclear …

Molecular chaperones and their associated co-chaperones are essential in health and
disease as they are key facilitators of protein-folding, quality control and function. In …