Replication protein A: single‐stranded DNA's first responder: dynamic DNA‐interactions allow replication protein A to direct single‐strand DNA intermediates into …
Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …
Structure and allostery of the chaperonin GroEL
HR Saibil, WA Fenton, DK Clare, AL Horwich - Journal of molecular biology, 2013 - Elsevier
Chaperonins are intricate allosteric machines formed of two back-to-back, stacked rings of
subunits presenting end cavities lined with hydrophobic binding sites for nonnative …
subunits presenting end cavities lined with hydrophobic binding sites for nonnative …
Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy
Aneuploidy—the state of having uneven numbers of chromosomes—is a hallmark of cancer
and a feature identified in yeast from diverse habitats,,,. Recent studies have shown that …
and a feature identified in yeast from diverse habitats,,,. Recent studies have shown that …
Adapting to stress—chaperome networks in cancer
In this Opinion article, we aim to address how cells adapt to stress and the repercussions
chronic stress has on cellular function. We consider acute and chronic stress-induced …
chronic stress has on cellular function. We consider acute and chronic stress-induced …
[HTML][HTML] The role of Hsp90 in protein complex assembly
T Makhnevych, WA Houry - Biochimica et Biophysica Acta (BBA)-Molecular …, 2012 - Elsevier
Hsp90 is a ubiquitous and essential molecular chaperone that plays central roles in many
signaling and other cellular pathways. The in vivo and in vitro activity of Hsp90 depends on …
signaling and other cellular pathways. The in vivo and in vitro activity of Hsp90 depends on …
The KMN protein network–chief conductors of the kinetochore orchestra
D Varma, ED Salmon - Journal of cell science, 2012 - journals.biologists.com
Successful completion of mitosis requires that sister kinetochores become attached end-on
to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming …
to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming …
Jasmonate signalling in Arabidopsis involves SGT1b–HSP70–HSP90 chaperone complexes
XC Zhang, YA Millet, Z Cheng, J Bush, FM Ausubel - Nature plants, 2015 - nature.com
Plant hormones play pivotal roles in growth, development and stress responses. Although it
is essential to our understanding of hormone signalling, how plants maintain a steady state …
is essential to our understanding of hormone signalling, how plants maintain a steady state …
[HTML][HTML] CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state
KE Gascoigne, IM Cheeseman - The Journal of cell biology, 2013 - ncbi.nlm.nih.gov
Accurate chromosome segregation requires assembly of the multiprotein kinetochore
complex. Prior work has identified more than 100 different kinetochore components in …
complex. Prior work has identified more than 100 different kinetochore components in …
HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE
T Kim, WY Kim, S Fujiwara, J Kim… - Proceedings of the …, 2011 - National Acad Sciences
The autoregulatory loops of the circadian clock consist of feedback regulation of
transcription/translation circuits but also require finely coordinated cytoplasmic and nuclear …
transcription/translation circuits but also require finely coordinated cytoplasmic and nuclear …
Hsp70-hsp90 chaperone networking in protein-misfolding disease
C Prodromou, X Aran-Guiu, J Oberoi, L Perna… - The Networking of …, 2022 - Springer
Molecular chaperones and their associated co-chaperones are essential in health and
disease as they are key facilitators of protein-folding, quality control and function. In …
disease as they are key facilitators of protein-folding, quality control and function. In …