Neutrophils under the microscope: neutrophil dynamics in infection, inflammation, and cancer revealed using intravital imaging

AO Yam, A Jakovija, C Gatt, T Chtanova - Frontiers in Immunology, 2024 - frontiersin.org
Neutrophils rapidly respond to inflammation resulting from infection, injury, and cancer.
Intravital microscopy (IVM) has significantly advanced our understanding of neutrophil …

Association and temporal sequence of pneumonia and gastrointestinal bleeding after acute ischemic stroke

R Zhang, H Hou, X Zhao, L Liu, Y Wang, G Liu… - BMC …, 2024 - Springer
Background Stroke-associated pneumonia (SAP) and gastrointestinal bleeding (GIB) are
common medical complications after stroke. The previous study suggested a strong …

[HTML][HTML] Proteomic Characterization of 1000 Human and Murine Neutrophils Freshly Isolated From Blood and Sites of Sterile Inflammation

S Ghosh, AA Tuz, M Stenzel, V Singh, M Richter… - Molecular & Cellular …, 2024 - Elsevier
Highlights•Proteome analysis of as few as 1000 neutrophils.•Spectral library of human and
mouse resting circulatory neutrophils.•A webserver for neutrophil protein copy numbers in …

Delayed DNase-I Administration but Not Gasdermin-D Inhibition Induces Hemorrhagic Transformation After Transient Focal Cerebral Ischemia in Mice

D Yin, C Wang, V Singh, AA Tuz, TR Doeppner… - Stroke, 2024 - ahajournals.org
Polymorphonuclear neutrophils are early invaders of the ischemic brain and exacerbate
brain damage. 1, 2 Neutrophil-released extracellular DNA traps significantly contribute to …

Differential action modes of Neutrophil Extracellular Trap-targeted drugs define T cell responses in SARS-CoV-2 infection.

CS Bonilha, FP Veras, AS Ramos, GF Gomes… - bioRxiv, 2024 - biorxiv.org
Neutrophil extracellular traps (NETs) play a dual role in SARS-CoV-2 infection, aiding early
immune defense but also contributing to lung damage. While NET targeting may improve …