Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Abstract Purpose of Review The evolving information of the initiation, tumor cell
heterogeneity, and plasticity of childhood neuroblastoma has opened up new perspectives …

MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene
copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA) …

Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

Background Neuroblastoma is the most common solid tumor in infants accounting for
approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma …

Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations …

The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while
recurrent copy number alterations are present in most high-risk cases. Here, we identify …

Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult
to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue …

Mutations in genes encoding SWI/SNF chromatin remodeling complexes are found in
approximately 20% of all human cancers, with ARID1A being the most frequently mutated …

To achieve the very high oncoprotein levels required to drive the malignant state cancer
cells utilise the ubiquitin proteasome system to upregulate transcription factor levels. Here …