Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

Familial amyloidotic polyneuropathy (FAP) is an inherited autosomal dominant disease that
is commonly caused by accumulation of deposits of transthyretin (TTR) amyloid around …

We have developed a statistical mechanics algorithm, TANGO, to predict protein
aggregation. TANGO is based on the physico-chemical principles of β-sheet formation …

The deposition of fibrils and amorphous aggregates of transthyretin (TTR) in patient tissues
is a hallmark of TTR amyloid disease, but the molecular details of amyloidogenesis are …

Amyloid fibril formation and deposition is a common feature of a wide range of fatal diseases
including spongiform encephalopathies, Alzheimer's disease, and familial amyloidotic …

The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon
dissociation and monomer unfolding. The aggregation of transthyretin has been reported as …

Motivation: The prediction of protein stability change upon mutations is key to understanding
protein folding and misfolding. At present, methods are available to predict stability changes …

Studies of large proteins, protein complexes, and membrane protein complexes pose new
challenges, most notably the need for increased ion mobility (IM) and mass spectrometry …

Amyloid fibril deposition is associated with over 20 degenerative diseases, including
Alzheimer's, Parkinson's, and prion diseases. Although research over the last few years has …

Urea denaturation studies were carried out as a function of transthyretin (TTR) concentration
to quantify the thermodynamically linked quaternary and tertiary structural stability and to …