The biology of general anesthesia from paramecium to primate
MB Kelz, GA Mashour - Current Biology, 2019 - cell.com
General anesthesia serves a critically important function in the clinical care of human
patients. However, the anesthetized state has foundational implications for biology because …
patients. However, the anesthetized state has foundational implications for biology because …
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
The Concise Guide to PHARMACOLOGY 2013/14: ion channels
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: a pilot study
Objectives Sleep, which comprises of rapid eye movement (REM) and non-REM stages 1–3
(N1–N3), is a natural occurring state of decreased arousal that is crucial for normal …
(N1–N3), is a natural occurring state of decreased arousal that is crucial for normal …
Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only
All cells necessarily contain tens, if not hundreds, of carriers for nutrients and intermediary
metabolites, and the human genome codes for more than 1000 carriers of various kinds …
metabolites, and the human genome codes for more than 1000 carriers of various kinds …
The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so
A recent paper in this journal sought to counter evidence for the role of transport proteins in
effecting drug uptake into cells, and questions that transporters can recognize drug …
effecting drug uptake into cells, and questions that transporters can recognize drug …
[PDF][PDF] Intraoperative awareness
Intraoperative Awareness Page 1 Intraoperative Awareness From Ether Day to THRIVE George
A. Mashour, MD, Ph.D. Robert B. Sweet Professor & Chair, Department of Anesthesiology …
A. Mashour, MD, Ph.D. Robert B. Sweet Professor & Chair, Department of Anesthesiology …
Role of GABAA receptors in the physiology and pharmacology of sleep
R Winsky‐Sommerer - European Journal of Neuroscience, 2009 - Wiley Online Library
Most sedative‐hypnotics used in insomnia treatment target the γ‐aminobutyric acid (GABA)
A receptors. A vast repertoire of GABAA receptor subtypes has been identified and displays …
A receptors. A vast repertoire of GABAA receptor subtypes has been identified and displays …
Activation of orexin system facilitates anesthesia emergence and pain control
Orexin (also known as hypocretin) neurons in the hypothalamus play an essential role in
sleep–wake control, feeding, reward, and energy homeostasis. The likelihood of anesthesia …
sleep–wake control, feeding, reward, and energy homeostasis. The likelihood of anesthesia …
Electroencephalographic variation during end maintenance and emergence from surgical anesthesia
D Chander, PS García, JN MacColl, S Illing… - PLoS one, 2014 - journals.plos.org
The re-establishment of conscious awareness after discontinuing general anesthesia has
often been assumed to be the inverse of loss of consciousness. This is despite the obvious …
often been assumed to be the inverse of loss of consciousness. This is despite the obvious …