Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Neurogenic inflammation, a well-defined pathophysiologial process is characterized by the
release of potent vasoactive neuropeptides, predominantly calcitonin gene-related peptide …

Glyceryl trinitrate is administered as a provocative test for migraine pain. Glyceryl trinitrate
causes prolonged mechanical allodynia in rodents, which temporally correlates with …

The existence of the neural control of mast cell functions has long been proposed. Mast cells
(MCs) are localized in association with the peripheral nervous system (PNS) and the brain …

Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …

Background According to our previous study, microglia P2X4 receptors (P2X4Rs) play a
pivotal role in the central sensitization of chronic migraine (CM). However, the molecular …

Migraine is a disease for which there is still no defined pathophysiological etiology and few
translational models. The organic nitrate nitroglycerin has been in use as an experimental …

Background Knowledge of exact signalling events during migraine attacks is lacking.
Various substances are known to trigger migraine attacks in patients and calcitonin gene …