[HTML][HTML] Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …
disease by producing complex extracellular matrix and creating signaling niches through …
Collagen in wound healing
Normal wound healing progresses through inflammatory, proliferative and remodeling
phases in response to tissue injury. Collagen, a key component of the extracellular matrix …
phases in response to tissue injury. Collagen, a key component of the extracellular matrix …
Wound healing: cellular mechanisms and pathological outcomes
HN Wilkinson, MJ Hardman - Open biology, 2020 - royalsocietypublishing.org
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …
[HTML][HTML] Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression
Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …
The role of myofibroblasts in physiological and pathological tissue repair
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
TGF-β1–a truly transforming growth factor in fibrosis and immunity
Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
Single cell transcriptomic landscape of diabetic foot ulcers
Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …
remains incompletely understood. Here, we profile 174,962 single cells from the foot …
Role of fibroblasts in wound healing and tissue remodeling on Earth and in space
F Cialdai, C Risaliti, M Monici - Frontiers in bioengineering and …, 2022 - frontiersin.org
Wound healing (WH) and the role fibroblasts play in the process, as well as healing
impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We …
impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We …
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas
XY Fu-Shin, PSY Lee, L Yang, N Gao, Y Zhang… - Progress in retinal and …, 2022 - Elsevier
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …
several underlying pathophysiological mechanisms, some of which are still uncertain. The …
Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate.
Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here …
Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here …