Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

One of the most captivating questions in neuroscience revolves around the brain's ability to
efficiently and durably capture and store information. It must process continuous input from …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

Microglia have emerged as critical regulators of synapse development and circuit formation
in the healthy brain. To date, examination of microglia in such processes has largely been …

Synapses between excitatory neurons in the cortex and hippocampus are typically made
onto spines, tiny thorn-like protrusions from dendrites (Yuste, 2010). In the 2000s, long-term …

Genetically defined subgroups of inhibitory interneurons are thought to play distinct roles in
learning, but heterogeneity within these subgroups has limited our understanding of the …