[HTML][HTML] Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

P Azzam, M Mroueh, M Francis… - …, 2020 - ncbi.nlm.nih.gov
Head and neck cancer (HNC) is the sixth most common human malignancy with a global
incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective …

Targeting estrogen signaling in the radiation-induced neurodegeneration: a possible role of phytoestrogens

S Mitra, R Dash, M Sohel, A Chowdhury… - Current …, 2023 - benthamdirect.com
Radiation for medical use is a well-established therapeutic method with an excellent
prognosis rate for various cancer treatments. Unfortunately, a high dose of radiation therapy …

[HTML][HTML] Advances in the study of the molecular biological mechanisms of radiation-induced brain injury

C Gan, W Li, J Xu, L Pang, L Tang, S Yu… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Radiation therapy is one of the most commonly used treatments for head and neck cancers,
but it often leads to radiation-induced brain injury. Patients with radiation-induced brain …

[HTML][HTML] Apelin receptor homodimer inhibits apoptosis in vascular dementia

D Wang, Y Wang, M Shan, J Chen, H Wang… - Experimental cell …, 2021 - Elsevier
Apelin receptor (APJ), a member of family A of the G protein-coupled receptors (GPCRs), is
a potential pharmaceutical target for diseases of the nervous system. Our previous work …

Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway

AH Abdelhamid, EM Mantawy, RS Said… - Toxicology and Applied …, 2024 - Elsevier
Radiation-induced cognitive impairment has recently fueled scientific interest with an
increasing prevalence of cancer patients requiring whole brain irradiation (WBI) in their …

[HTML][HTML] Cognitive dysfunction induced by cranial radiotherapy: mechanisms and therapeutic methods

X Li, Z Ding - Brain Research Bulletin, 2024 - Elsevier
Cranial radiotherapy can damage normal brain tissues, inducing cognitive dysfunction in
patients. Radiotherapy-induced cognitive dysfunction is associated with hippocampal injury …

Efficacy of nimodipine combined with latanoprost in treating open-angle glaucoma and its influence on ocular hemodynamics and visual field defects

HP Duan, R Liu - Drug Design, Development and Therapy, 2023 - Taylor & Francis
Background Open-angle glaucoma is a common ophthalmic disease, which has a great
impact on the vision of middle-aged and elderly people. Medication plays an important role …

Region-specific reduction of parvalbumin neurons and behavioral changes in adult mice following single exposure to cranial irradiation

H Ueno, S Suemitsu, S Murakami… - … Journal of Radiation …, 2019 - Taylor & Francis
Purpose: Ionizing irradiation has several long-term effects including progressive cognitive
impairment. Cognitive deterioration generally appears to be caused by abnormalities in the …

Repurposing of Various Current Medicines as Radioprotective Agents

R Kaur, DK Lang, H Singh, A Arora… - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Background: The side effects of ionising radiation include skin changes, dry mouth, hair loss,
low blood count, and the mutagenic effect on normal cells when utilized in radiotherapy for …

Fractionated brain X-irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior in mice

LE Kuil, R Seigers, M Loos, MC de Gooijer, A Compter… - Heliyon, 2024 - cell.com
Whole brain radiotherapy (WBRT) is used to improve tumor control in patients with primary
brain tumors, or brain metastasis from various primary tumors to improve tumor control …