Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

Cyclodextrins (CDs) are a series of cyclic oligosaccharides formed by amylose under the
action of CD glucosyltransferase that is produced by Bacillus. After being modified by …

Disruption of protein geranylgeranylation via inhibition of geranylgeranyl diphosphate
synthase (GGDPS) represents a novel therapeutic strategy for a variety of malignancies …

Systematically studying the lipophilicity of phosphorus compounds is of great importance for
many chemical and biological fields and particularly for medicinal chemistry. Here, we report …

Toxoplasmosis, an infectious zoonotic disease caused by the apicomplexan parasite
Toxoplasma gondii (T. gondii), is a major worldwide health problem. However, there are …

Gold nanoraspberries were synthesized by a seed-mediated synthesis with polyethylene
glycol-functionalized bisphosphonates. The original structure shifted the optical absorption …

Bisphosphonates are well established pharmaceutical drugs with wide applications in
medicine. Nevertheless, the side chain and the nature of phosphorous groups could induce …

Based on crystallographic data of the complexes 2-alkyl (amino) ethyl-1, 1-bisphosphonates–
Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1, 1-bisphosphonic acids …

As an extension of our project aimed at the search for new chemotherapeutic agents against
Chagas disease and toxoplasmosis, several 1, 1-bisphosphonates were designed …

Leishmaniasis is a disease that is a significant problem for people, especially in tropical
regions of the world. Current drug therapies to treat the disease are expensive, not very …