The endoplasmic reticulum (ER) in animal cells is an extensive, morphologically continuous
network of membrane tubules and flattened cisternae. The ER is a multifunctional organelle; …

Abstract mRNA localization is a common mechanism for targeting proteins to regions of the
cell where they are required. It has an essential role in localizing cytoplasmic determinants …

Cellular processes such as proliferation, differentiation, and adaptation to environmental
changes are regulated by protein phosphorylation. Development of sensitive and …

Gene activation in eukaryotes requires chromatin remodeling complexes like Swi/Snf and
histone acetylases like SAGA. How these factors are recruited to promoters is not yet …

The actin cytoskeleton provides the structural basis for cell polarity in Saccharomyces
cerevisiae as well as most other eukaryotes. In Part I of this two-part commentary, presented …

A pharmacological screen identified the H+ and K+ ATPase transporter as obligatory for
normal orientation of the left-right body axis in Xenopus. Maternal H+/K+-ATPase mRNA is …

Asymmetric localization of proteins plays a key role in many cellular processes, including
cell polarity and cell fate determination. Using DNA microarray analysis, we identified a …

The ability to polarize is a fundamental property of cells. The yeast Saccharomyces
cerevisiae has proven to be a fertile ground for dissecting the molecular mechanisms that …

The myosin family of actin-based molecular motors consists of 15 known classes that are
structurally distinct based on comparisons of the primary structure of the motor domains of …

The DNA-binding domains of eucaryotic GATA factors comprise a four-cysteine Zn finger
and an adjacent basic region. Fungal GATA factors regulate nitrogen metabolism, light …