The state of areflexia and muscle weakness that immediately follows a spinal cord injury
(SCI) is gradually replaced by the recovery of neuronal and network excitability, leading to …

Body-weight supported locomotor training (BWST) promotes recovery of load-bearing
stepping in lower mammals, but its efficacy in individuals with a spinal cord injury (SCI) is …

A phase 1 open-label, non-randomized clinical trial was conducted to determine feasibility
and safety of autologous human Schwann cell (ahSC) transplantation accompanied by …

High-intensity locomotor exercise is suggested to contribute to improved recovery of
locomotor function after neurological injury. This may be secondary to exercise-intensity …

During the last 50 years, the serotonergic (5-HT) system was reported to exert a complex
modulation of locomotor activity. Here, we focus on two key factors that likely contribute to …

Pain is a common concern among persons with spinal cord injury. Incidence of pain
following SCI can range anywhere from 48 to 92%(Britell & Mariano 1991; Cohen et al …

Abstract Changes in descending serotonergic innervation of spinal neural activity have been
implicated in symptoms of paralysis, spasticity, sensory disturbances and pain following …

The safety and efficacy of pharmacological and cellular transplantation strategies are
currently being evaluated in people with spinal cord injury (SCI). In studies of people with …

Incomplete spinal cord injury (iSCI) often results in significant motor impairments that lead to
decreased functional mobility. Loss of descending serotonergic (5HT) input to spinal circuits …

Spasticity attributable to exaggerated stretch reflex pathways, particularly affecting the ankle
plantar flexors, often impairs overground walking in persons with incomplete spinal cord …