With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s,
thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) …

Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome
P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a …

Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Drug metabolizing enzymes participate in the neutralizing of xenobiotics and
biotransformation of drugs. Human cytochrome P450, particularly CYP1A1, CYP2C9 …

Background Tamarindus indica (T. indica) is a medicinal plant with many biological activities
including anti-diabetic, hypolipidaemic and anti-bacterial activities. A recent study …

In contrast to studies focused on cigarette smoking and risk of breast cancer occurrence, this
study explored the influence of smoking on breast cancer recurrence and progression. The …

Breast cancer is associated to estrogen exposure. Allelic variants involved in estrogen
metabolism might change the risk of developing this neoplasia. We examined the potential …

Both obesity and breast cancer incidence increased dramatically during two recent decades
in a rapidly changing society in northern Iran. In this study, we examined the ability of body …

OBJECTIVES: We examined the influence of CYP1A1 A4889G and T6235C polymorphisms
on the risk of sporadic breast cancer. METHODS: DNA from 742 sporadic breast cancer …

To discover new selective mechanism-based P450 inhibitors, eight 7-ethynylcoumarin
derivatives were prepared through a facile two-step synthetic route. Cytochrome P450 …