[HTML][HTML] A comprehensive review of amyotrophic lateral sclerosis

S Zarei, K Carr, L Reiley, K Diaz, O Guerra… - Surgical neurology …, 2015 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?

D Petrov, C Mansfield, A Moussy… - Frontiers in aging …, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of
30,000 patients a year worldwide. The median reported survival time since onset ranges …

Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly

A Bian, Y Ma, X Zhou, Y Guo, W Wang, Y Zhang… - BMC musculoskeletal …, 2020 - Springer
Background Age-related sarcopenia is a serious global health issue in elderly individuals
and for the community as it induces disability and significant economic burden. The purpose …

Current state and future directions in the therapy of ALS

L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

Y Hua, K Sahashi, F Rigo, G Hung, G Horev… - Nature, 2011 - nature.com
Spinal muscular atrophy (SMA) is a motor neuron disease and the leading genetic cause of
infant mortality; it results from loss-of-function mutations in the survival motor neuron 1 …

Rodent models of amyotrophic lateral sclerosis

T Philips, JD Rothstein - Current protocols in pharmacology, 2015 - Wiley Online Library
Abstract Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and
lower motor neurons in the central nervous system. Patients with ALS develop extensive …

Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

H Mitsumoto, BR Brooks, V Silani - The Lancet Neurology, 2014 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is one of the most rapidly progressive
neurodegenerative diseases of unknown cause. Riluzole is the only drug that slows disease …

Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy

TB Sampaio, AS Savall, MEZ Gutierrez… - Neural regeneration …, 2017 - journals.lww.com
Neurotrophic factors comprise essential secreted proteins that have several functions in
neural and non-neural tissues, mediating the development, survival and maintenance of …

Mesenchymal stromal cell therapies for neurodegenerative diseases

NP Staff, DT Jones, W Singer - Mayo Clinic Proceedings, 2019 - Elsevier
Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

Neurotrophic and neuroregenerative effects of GH/IGF1

VE Bianchi, V Locatelli, L Rizzi - International journal of molecular …, 2017 - mdpi.com
Introduction. Human neurodegenerative diseases increase progressively with age and
present a high social and economic burden. Growth hormone (GH) and insulin-like growth …