Mitochondria contain two aqueous subcompartments, the matrix and the intermembrane
space (IMS). The matrix is enclosed by both the inner and outer mitochondrial membranes …

Mitochondria are double-membrane organelles that contain their own genome, the
mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin. Mitochondria are …

Redox processes are at the heart of universal life processes, such as metabolism, signaling,
or folding of secreted proteins. Redox landscapes differ between cell compartments and are …

Discoveries of diverse microbial eukaryotes and their inclusion in comprehensive
phylogenomic analyses have crucially re-shaped the eukaryotic tree of life in the 21st …

The mitochondrial intermembrane space (IMS) is the most constricted sub-mitochondrial
compartment, housing only about 5% of the mitochondrial proteome, and yet is endowed …

The mitochondrial intermembrane space hosts a machinery for oxidative protein folding, the
mitochondrial disulfide relay. This machinery imports a large number of soluble proteins into …

Molecular oxygen (O 2) is a universal electron acceptor that enables ATP synthesis through
mitochondrial respiration in all metazoans. Consequently, hypoxia (low O 2) has arisen as …

In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the
optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival …

The mitochondrial intermembrane space (IMS) houses a large spectrum of proteins with
distinct and critical functions. Protein import into this mitochondrial sub-compartment is …

The intermembrane space (IMS) is a very small mitochondrial sub‐compartment with critical
relevance for many cellular processes. IMS proteins fulfil important functions in transport of …