Breast cancer is a complex disease which is found as the second cause of cancer‐
associated death among women. Accumulating of evidence indicated that various factors …

The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Inhibitory Smads (I-Smads) have conserved carboxy-terminal MH2 domains but highly
divergent amino-terminal regions when compared with receptor-regulated Smads (R …

Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …

The differentiation plasticity of epithelial cells that mediates TGF-β-induced EMT and
reversion from mesenchymal to epithelial phenotype are increasingly seen as integral …

Peritoneal metastasis is a primary metastatic route for gastric cancers, and the mechanisms
underlying this process are still unclear. Peritoneal mesothelial cells (PMCs) undergo …

Tumor recurrence and metastases are the major obstacles to improving the prognosis of
patients with hepatocellular carcinoma (HCC). To identify novel risk factors associated with …

Transforming growth factor-β (TGF-β) is a common mediator of cancer progression and
fibrosis. Fibrosis can be a significant pathology in multiple organs, including the heart. In this …

Epithelial-mesenchymal transition (EMT) is a major contributor to metastatic progression and
is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are …