The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Abstract Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in
cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections …

We previously documented that M2-like macrophages exert a hepatoprotective effect in
acute-on-chronic liver failure (ACLF) by inhibiting necroptosis signalling. Nevertheless, the …

Cardiac fibrosis is a hallmark of various cardiovascular diseases, which is quite commonly
found in obesity, and may contribute to the increased incidence of heart failure arrhythmias …

Galectin-3 (Gal-3) participates in myocardial fibrosis (MF) in a variety of ways. Inhibiting the
expression of Gal-3 can effectively interfere with MF. This study aimed to explore the value of …

Abnormal cardiac function in the setting of cirrhosis and in the absence of a primary cardiac
disease is known as cirrhotic cardiomyopathy. The pathogenesis of cirrhotic cardiomyopathy …

Background The prevalence of cardiac fibrosis, intricately linked to various cardiovascular
diseases, continues to rise. Aconite, a traditional Chinese herb renowned for its …

Peroxisome proliferator-activated receptor (PPAR) δ is a major transcriptional regulator of
cardiac energy metabolism with pleiotropic properties, including anti-inflammatory, anti …

Background Frailty is one of the most problematic expressions of population aging, but its
underlying mechanism has not been fully elucidated. Circulating galectin-3 (Gal-3) is …

Senescence is a physiological and pathological cellular program triggered by various types
of cellular stress. Senescent cells exhibit multiple characteristic changes. Among them, the …