Inflammatory effects of particulate matter air pollution
Air pollution is an important cause of non-communicable diseases globally with particulate
matter (PM) as one of the main air pollutants. PM is composed of microscopic particles that …
matter (PM) as one of the main air pollutants. PM is composed of microscopic particles that …
The need for clean air: the way air pollution and climate change affect allergic rhinitis and asthma
I Eguiluz‐Gracia, AG Mathioudakis, S Bartel… - Allergy, 2020 - Wiley Online Library
Air pollution and climate change have a significant impact on human health and well‐being
and contribute to the onset and aggravation of allergic rhinitis and asthma among other …
and contribute to the onset and aggravation of allergic rhinitis and asthma among other …
Role for NLRP3 inflammasome–mediated, IL-1β–dependent responses in severe, steroid-resistant asthma
RY Kim, JW Pinkerton, AT Essilfie… - American journal of …, 2017 - atsjournals.org
Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the …
emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the …
More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
Understanding the pathogenesis of occupational coal and silica dust-associated lung disease
Workers in the mining and construction industries are at increased risk of respiratory and
other diseases as a result of being exposed to harmful levels of airborne particulate matter …
other diseases as a result of being exposed to harmful levels of airborne particulate matter …
Microbiome effects on immunity, health and disease in the lung
Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases
M Sayan, BT Mossman - Particle and fibre toxicology, 2015 - Springer
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger
signals and initiating inflammation, was first introduced approximately a decade ago …
signals and initiating inflammation, was first introduced approximately a decade ago …
NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter
R Zheng, L Tao, H Jian, Y Chang, Y Cheng… - Ecotoxicology and …, 2018 - Elsevier
Airborne fine particulate matter (PM 2.5) has been known capable of causing lung
inflammation and fibrosis, as a result of a series of chronic respiration diseases. Although …
inflammation and fibrosis, as a result of a series of chronic respiration diseases. Although …
Inflammasomes in the lung
Innate immune responses act as first line defences upon exposure to potentially noxious
stimuli. The innate immune system has evolved numerous intracellular and extracellular …
stimuli. The innate immune system has evolved numerous intracellular and extracellular …