Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Acidity‐activatable dynamic nanoparticles boosting ferroptotic cell death for immunotherapy of cancer

R Song, T Li, J Ye, F Sun, B Hou, M Saeed… - Advanced …, 2021 - Wiley Online Library
Immunotherapy shows promising therapeutic potential for long‐term tumor regression.
However, current cancer immunotherapy displays a low response rate due to insufficient …

Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Strategies for bone regeneration: from graft to tissue engineering

G Battafarano, M Rossi, V De Martino… - International journal of …, 2021 - mdpi.com
Bone is a regenerative organ characterized by self-renewal ability. Indeed, it is a very
dynamic tissue subjected to continuous remodeling in order to preserve its structure and …

International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase …

J Galipeau, M Krampera, J Barrett, F Dazzi, RJ Deans… - Cytotherapy, 2016 - Elsevier
Mesenchymal stromal cells (MSCs) as a pharmaceutical for ailments characterized by
pathogenic autoimmune, alloimmune and inflammatory processes now cover the spectrum …

Mesenchymal stromal cell secretion of programmed death-1 ligands regulates T cell mediated immunosuppression

LC Davies, N Heldring, N Kadri, K Le Blanc - Stem cells, 2017 - academic.oup.com
Mesenchymal stromal cells (MSCs) exert broad immunosuppressive potential, modulating
the activity of cells of innate and adaptive immune systems. As MSCs become accepted as a …

TNF-α and IFN-γ participate in improving the immunoregulatory capacity of mesenchymal stem/stromal cells: Importance of cell–cell contact and extracellular vesicles

L López-García, ME Castro-Manrreza - International journal of molecular …, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) have an immunoregulatory capacity and have
been used in different clinical protocols requiring control of the immune response. However …

[HTML][HTML] Targeting regulated cell death in tumor nanomedicines

Q Zeng, X Ma, Y Song, Q Chen, Q Jiao, L Zhou - Theranostics, 2022 - ncbi.nlm.nih.gov
Nanomedicines hold great potential in anticancer therapy by modulating the biodistribution
of nanomaterials and initiating targeted oxidative stress damage, but they are also limited by …