Measuring and modeling energy and power consumption in living microbial cells with a synthetic ATP reporter
Background Adenosine triphosphate (ATP) is the main energy carrier in living organisms,
critical for metabolism and essential physiological processes. In humans, abnormal …
critical for metabolism and essential physiological processes. In humans, abnormal …
Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield
Microbes may maximize the number of daughter cells per time or per amount of nutrients
consumed. These two strategies correspond, respectively, to the use of enzyme-efficient or …
consumed. These two strategies correspond, respectively, to the use of enzyme-efficient or …
Analysis of the evolution of resistance to multiple antibiotics enables prediction of the Escherichia coli phenotype-based fitness landscape
The fitness landscape represents the complex relationship between genotype or phenotype
and fitness under a given environment, the structure of which allows the explanation and …
and fitness under a given environment, the structure of which allows the explanation and …
Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism
Growth rate and yield are fundamental features of microbial growth. However, we lack a
mechanistic and quantitative understanding of the rate-yield relationship. Studies pairing …
mechanistic and quantitative understanding of the rate-yield relationship. Studies pairing …
Bacterial fitness landscapes stratify based on proteome allocation associated with discrete aero-types
The fitness landscape is a concept commonly used to describe evolution towards optimal
phenotypes. It can be reduced to mechanistic detail using genome-scale models (GEMs) …
phenotypes. It can be reduced to mechanistic detail using genome-scale models (GEMs) …
The effect of natural selection on the propagation of protein expression noise to bacterial growth
LHJ Krah, R Hermsen - PLoS computational biology, 2021 - journals.plos.org
In bacterial cells, protein expression is a highly stochastic process. Gene expression noise
moreover propagates through the cell and adds to fluctuations in the cellular growth rate. A …
moreover propagates through the cell and adds to fluctuations in the cellular growth rate. A …
Metabolic engineering of Escherichia coli to convert ethanol into L-tyrosine
H LIANG, Z Kang - 2023 - researchsquare.com
Utilizing ethanol derived from waste streams could establish shorter biosynthetic metabolic
pathways to produce target metabolites, such as acetyl-CoA-derived chemicals. We have …
pathways to produce target metabolites, such as acetyl-CoA-derived chemicals. We have …
[PDF][PDF] Bacterial fitness landscapes stratify based on proteome allocation associated with discrete aero-types
Y Gao - 2021 - scholar.archive.org
The fitness landscape is a concept commonly used to describe evolution towards optimal
phenotypes. It can be reduced to mechanistic detail using genome-scale models (GEMs) …
phenotypes. It can be reduced to mechanistic detail using genome-scale models (GEMs) …
[PDF][PDF] Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism
EJ O'Brien, D McCloskey, C Olson, RA LaCroix… - 2019 - core.ac.uk
Growth rate and yield are fundamental features of microbial growth. However, we lack a
mechanistic and quantitative understanding of the rate-yield relationship. Studies pairing …
mechanistic and quantitative understanding of the rate-yield relationship. Studies pairing …