Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Over the past three decades, considerable efforts have been expended on understanding
the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling …

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell
lymphoma most reported in Asia. We performed a comprehensive clinical, pathological and …

The presence of polyfunctional CD4+ T cells is often associated with favorable antitumor
immunity. We report here that persistent activation of signal transducer and activator of …

Signal transducer and activator of transcription (STAT) 3 and STAT5 are important
transcription factors that are able to mediate or even drive cancer progression through …

The contribution of γδ T cells to immune responses is associated with rapid secretion of
interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T …

Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …

The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …

Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known
about the regulatory processes that control the fluent and fragile balance that is called …

Determining the underlying cause of persistent eosinophilia is important for effective clinical
management but remains a diagnostic challenge in many cases. We identified STAT5B …