Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

The urothelium, which lines the inner surface of the renal pelvis, the ureters, and the urinary
bladder, not only forms a high-resistance barrier to ion, solute and water flux, and …

The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

The storage and periodic elimination of urine, termed micturition, requires a complex neural
control system to coordinate the activities of the urinary bladder, urethra, and urethral …

Purinergic signalling is involved in a number of physiological and pathophysiological
activities in the lower urinary tract. In the bladder of laboratory animals there is …

The clinical use of cyclophosphamide and ifosfamide is limited by a resultant bladder toxicity
which has been attributed to the metabolite acrolein. Another metabolite chloroacetaldehyde …

It is well established that lower urinary tract symptoms (LUTS), particularly urinary urgency
and incontinence, cause stress and anxiety for patients. However, there is mounting …

Understanding of the role of urothelium in regulating bladder function is continuing to
evolve. While the urothelium is thought to function primarily as a barrier for preventing …

The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical
contents of the lower urinary tract and the underlying tissues but also acts as a sensory …

The urothelium is a newly recognized sensory structure that detects bladder fullness. Pivotal
to this sensory role is the release of ATP from the urothelium. However, the routes for …