Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Profilin is a ubiquitously expressed protein well known as a key regulator of actin
polymerisation. The actin cytoskeleton is involved in almost all cellular processes including …

This review covers aspects of cofilin and profilin regulations and their influence on actin
polymerisation responsible for cell motility and metastasis. The regulation of their activity by …

Actin and microtubules play essential roles in aberrant cell processes that define and
converge in cancer including: signaling, morphology, motility, and division. Actin and …

Background Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively
malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that …

Rationale: The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) promotes
pathological mitochondrial fission during septic acute kidney injury. The mitochondrial open …

We conducted an RNA sequencing study to identify novel gene fusions in 80 discovery
dataset tumors collected from young patients with diffuse gastric cancer (DGC). Twenty-five …

The last two decades have witnessed a tremendous increase in cell biology data. Not least
is this true for studies of the dynamic organization of the microfilament and microtubule …

Bladder cancer (BC) is the second most common malignancy of the genitourinary system,
characterized by the highest recurrence rate of all cancers. Treatment options are limited; …

Abstract Structure and functional similarities of a recent protein's orthologs with its ancient
counterpart are largely determined by the configuration of evolutionary preservation of …