The amyloid-β pathway in Alzheimer's disease
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization
IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
SIA Cohen, S Linse, LM Luheshi… - Proceedings of the …, 2013 - National Acad Sciences
The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42
into amyloid fibrils and plaques has emerged as a central feature of the onset and …
into amyloid fibrils and plaques has emerged as a central feature of the onset and …
CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease
S Janelidze, H Zetterberg, N Mattsson… - Annals of clinical …, 2016 - Wiley Online Library
Objective The diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers for Alzheimer's
disease (AD) must be improved before widespread clinical use. This study aimed to …
disease (AD) must be improved before widespread clinical use. This study aimed to …
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
G Meisl, X Yang, E Hellstrand… - Proceedings of the …, 2014 - National Acad Sciences
The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering
from Alzheimer's disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal …
from Alzheimer's disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal …
Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease
Alzheimer's disease (AD) is characterized by β-amyloid plaques and intraneuronal τ
aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid …
aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid …
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide
In recent genome-wide association studies, the extracellular chaperone protein, clusterin,
has been identified as a newly-discovered risk factor in Alzheimer's disease. We have …
has been identified as a newly-discovered risk factor in Alzheimer's disease. We have …
Aβ42 and Aβ40: similarities and differences
The abnormal accumulation of amyloid‐β (Aβ) peptide in the brain is one of the most
important hallmarks of Alzheimer's disease. Aβ is an aggregation‐prone and toxic …
important hallmarks of Alzheimer's disease. Aβ is an aggregation‐prone and toxic …
Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans
ML Duennwald, AL Echeverria, J Shorter - PLoS biology, 2012 - journals.plos.org
How small heat shock proteins (sHsps) might empower proteostasis networks to control
beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that …
beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that …
Advances in mass spectrometry to unravel the structure and function of protein condensates
Membrane-less organelles assemble through liquid–liquid phase separation (LLPS) of
partially disordered proteins into highly specialized microenvironments. Currently, it is …
partially disordered proteins into highly specialized microenvironments. Currently, it is …