In recent decades, technological advantages have allowed scientists to isolate medicinal
compounds from marine organisms that exhibit unique structure and bioactivity. The …

Abnormal mitochondrial calcium ([Ca2+] m) handling and energy deficiency results in
cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded …

Arsenic (As), a metalloid chemical element, is classified as heavy metal. Previous studies
proposed that As induces vascular toxicity by inducing autophagy, apoptosis, and oxidative …

Throughout human life, an extensive and varied range of emerging environmental
contaminants, called endocrine disruptors (EDCs), cause adverse health effects, including in …

Myocardial infarction (MI) is a common and life-threatening manifestation of ischemic heart
diseases (IHD). The most important risk factor for MI is hypertension. Natural products from …

Ethnopharmacological relevance Crataegus leaves, flowers and fruits have been
traditionally used to improve blood circulation, numerous preclinical and clinical studies …

Cnidium monnieri (L.) Cusson, a member of the Apiaceae family, is rich in coumarins, such
as imperatorin and osthole. Cnidium monnieri fruit (CM) has a broad range of therapeutic …

Oxytocin receptor (OTR) activation at the spinal level produces antinociception. Some data
suggest that central OTR activation enhances social interaction via an increase of …

Aims Myocardial infarction (MI) is a common cause of mortality in patients with diabetes
mellitus (DM) and vascular dysfunction is a major component of diabetic cardiomyopathy …

8-Oxo-9-dihydromakomakine is a tetracyclic indole alkaloid extracted from leaves of the
Chilean tree Aristotelia chilensis. The present study investigated the effects of this alkaloid …