Advances in our understanding of the metabolism and molecular functions of polyamines
and their alterations in cancer have led to resurgence in the interest of targeting polyamine …

The natural amino acid hypusine (N δ-4-amino-2-hydroxybutyl (lysine)) is derived from the
polyamine spermidine, and occurs only in a single family of cellular proteins, eukaryotic …

The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been
assigned functions in both initiation and elongation. Additionally, it is implicated in …

The unusual basic amino acid, hypusine [N ε-(4-amino-2-hydroxybutyl)-lysine], is a modified
lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This …

In addition to the small and large ribosomal subunits, aminoacyl-tRNAs, and an mRNA,
cellular protein synthesis is dependent on translation factors. The eukaryotic translation …

During protein synthesis, ribosomes become stalled on polyproline-containing sequences,
unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and …

The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein
that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …

Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor
5A (eIF5A) has been studied principally in relation to the development and progression of …

Synthesis of polyproline proteins leads to translation arrest. To overcome this ribosome
stalling effect, bacteria depend on a specialized translation elongation factor P (EF‐P), being …

The eukaryotic initiation factor 5A (eIF5A) contains a polyamine-derived amino acid,
hypusine [N ε-(4-amino-2-hydroxybutyl) lysine]. Hypusine is formed post-translationally by …