Polyamine metabolism and cancer: treatments, challenges and opportunities
RA Casero Jr, T Murray Stewart, AE Pegg - Nature Reviews Cancer, 2018 - nature.com
Advances in our understanding of the metabolism and molecular functions of polyamines
and their alterations in cancer have led to resurgence in the interest of targeting polyamine …
and their alterations in cancer have led to resurgence in the interest of targeting polyamine …
Hypusine, a polyamine-derived amino acid critical for eukaryotic translation
MH Park, EC Wolff - Journal of Biological Chemistry, 2018 - ASBMB
The natural amino acid hypusine (N δ-4-amino-2-hydroxybutyl (lysine)) is derived from the
polyamine spermidine, and occurs only in a single family of cellular proteins, eukaryotic …
polyamine spermidine, and occurs only in a single family of cellular proteins, eukaryotic …
The translation factor eIF5A and human cancer
MB Mathews, JWB Hershey - Biochimica et Biophysica Acta (BBA)-Gene …, 2015 - Elsevier
The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been
assigned functions in both initiation and elongation. Additionally, it is implicated in …
assigned functions in both initiation and elongation. Additionally, it is implicated in …
Functional significance of eIF5A and its hypusine modification in eukaryotes
MH Park, K Nishimura, CF Zanelli, SR Valentini - Amino acids, 2010 - Springer
The unusual basic amino acid, hypusine [N ε-(4-amino-2-hydroxybutyl)-lysine], is a modified
lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This …
lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This …
The hypusine-containing translation factor eIF5A
TE Dever, E Gutierrez, BS Shin - Critical reviews in biochemistry …, 2014 - Taylor & Francis
In addition to the small and large ribosomal subunits, aminoacyl-tRNAs, and an mRNA,
cellular protein synthesis is dependent on translation factors. The eukaryotic translation …
cellular protein synthesis is dependent on translation factors. The eukaryotic translation …
Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome
C Schmidt, T Becker, A Heuer, K Braunger… - Nucleic acids …, 2016 - academic.oup.com
During protein synthesis, ribosomes become stalled on polyproline-containing sequences,
unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and …
unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and …
Role of eIF5A in mitochondrial function
M Barba-Aliaga, P Alepuz - International journal of molecular sciences, 2022 - mdpi.com
The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein
that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …
that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …
The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles
M Tauc, M Cougnon, R Carcy, N Melis, T Hauet… - Cell & Bioscience, 2021 - Springer
Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor
5A (eIF5A) has been studied principally in relation to the development and progression of …
5A (eIF5A) has been studied principally in relation to the development and progression of …
Stall no more at polyproline stretches with the translation elongation factors EF‐P and IF‐5A
Synthesis of polyproline proteins leads to translation arrest. To overcome this ribosome
stalling effect, bacteria depend on a specialized translation elongation factor P (EF‐P), being …
stalling effect, bacteria depend on a specialized translation elongation factor P (EF‐P), being …
Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development
K Nishimura, SB Lee, JH Park, MH Park - Amino acids, 2012 - Springer
The eukaryotic initiation factor 5A (eIF5A) contains a polyamine-derived amino acid,
hypusine [N ε-(4-amino-2-hydroxybutyl) lysine]. Hypusine is formed post-translationally by …
hypusine [N ε-(4-amino-2-hydroxybutyl) lysine]. Hypusine is formed post-translationally by …