An extracellular matrix (ECM) is a prerequisite for multicellular life. It is adapted to tissues
and constantly undergoes changes to preserve microenvironmental homeostasis. The ECM …

Epidermolysis bullosa (EB), a group of heritable skin fragility disorders, is characterized by
blistering, erosions and chronic ulcers in the skin and mucous membranes. In some forms …

Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …

A specialized basal lamina (sBL) mediates adhesion of certain epithelial cells to the tooth. It
is distinct because it does not contain collagens type IV and VII, is enriched in laminin-332 …

Organoid models provide powerful tools to study tissue biology and development in a dish.
Presently, organoids have not yet been developed from mouse tooth. Here, we established …

Objective Amelogenesis imperfecta (AI) is defined as inherited enamel malformations.
LAMA3 (laminin alpha‐3) encodes a critical protein component of the basement membrane …

At maturation stage of enamel development, a specialized basal lamina (sBL) was built
between ameloblasts and enamel. After the teeth eruption, the ameloblasts transform into …

The junctional epithelium (JE) is a specialized portion of the gingiva that seals off the tooth‐
supporting tissues from the oral environment. This relationship is achieved via a unique …

Tooth biomineralization is a dynamic and complicated process influenced by local and
systemic factors. Abnormal mineralization in teeth occurs when factors related to physiologic …

La hipomineralización del incisivo molar (HIM) es un defecto cualitativo del esmalte dental
que afecta a los primeros molares permanentes y, a menudo, en asociación con los …