Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …

Motile cilia are miniature, propeller-like extensions, emanating from many cell types across
the body. Their coordinated beating generates a directional fluid flow, which is essential for …

The neuroscience community has witnessed a tremendous expansion of glia research. Glial
cells are now on center stage with leading roles in the development, maturation, and …

The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …

Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine
disorders. The development of ciliated cells, their impact on CSF flow, and their function in …

Abstract Properties of the local internal environment of the adult brain are tightly controlled
providing a stable milieu essential for its normal function. The mechanisms involved in this …

Motile cilia are miniature, whip-like organelles whose beating generates a directional fluid
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …

As an optically transparent model organism with an endothelial blood-brain barrier (BBB),
zebrafish offer a powerful tool to study the vertebrate BBB. However, the precise …

Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal
fluid barrier (BCSFB) in the developing and mature brain. The ChP is considered the primary …