Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …

Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription
factors that has evolved by gene/genome duplication. FOX family members have undergone …

According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …

Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental
challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase …

Investigation of cell-cycle kinetics in mammalian pancreatic β cells has mostly focused on
transition from the quiescent (G0) to G1 phase. Here, we report that centromere protein A …

Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent
regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated …

Forkhead box (FOX) proteins are a wing-like helix family of transcription factors in the DNA-
binding region. By mediating the activation and inhibition of transcription and interactions …

Background Over the last decades, various approaches have been explored to restore
sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new …

Many theories have been advanced to better understand why β cell function and structure
relentlessly deteriorate during the course of type 2 diabetes (T2D). These theories include …

The calcium-sensing receptor (CaSR) is a family C G-protein–coupled receptor that plays a
pivotal role in extracellular calcium homeostasis. The CaSR is also highly expressed in …