Fox transcription factors: from development to disease
ML Golson, KH Kaestner - Development, 2016 - journals.biologists.com
Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …
from yeast to humans. They regulate diverse biological processes both during development …
Forkhead transcription factors in health and disease
L Herman, AL Todeschini, RA Veitia - Trends in Genetics, 2021 - cell.com
Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription
factors that has evolved by gene/genome duplication. FOX family members have undergone …
factors that has evolved by gene/genome duplication. FOX family members have undergone …
DYRK1A inhibitors as potential therapeutics for β-cell regeneration for diabetes
K Kumar, C Suebsuwong, P Wang… - Journal of Medicinal …, 2021 - ACS Publications
According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …
Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells
P Wang, E Karakose, C Argmann… - The Journal of …, 2022 - Am Soc Clin Investig
Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental
challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase …
challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase …
Insulin signaling regulates the FoxM1/PLK1/CENP-A pathway to promote adaptive pancreatic β cell proliferation
J Shirakawa, M Fernandez, T Takatani, A El Ouaamari… - Cell metabolism, 2017 - cell.com
Investigation of cell-cycle kinetics in mammalian pancreatic β cells has mostly focused on
transition from the quiescent (G0) to G1 phase. Here, we report that centromere protein A …
transition from the quiescent (G0) to G1 phase. Here, we report that centromere protein A …
Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress
Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent
regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated …
regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated …
FOXM1: functional roles of FOXM1 in non-malignant diseases
Z Zhang, M Li, T Sun, Z Zhang, C Liu - Biomolecules, 2023 - mdpi.com
Forkhead box (FOX) proteins are a wing-like helix family of transcription factors in the DNA-
binding region. By mediating the activation and inhibition of transcription and interactions …
binding region. By mediating the activation and inhibition of transcription and interactions …
[HTML][HTML] An update on pancreatic regeneration mechanisms: searching for paths to a cure for type 2 diabetes
L Soldovieri, G Di Giuseppe, G Ciccarelli, G Quero… - Molecular …, 2023 - Elsevier
Background Over the last decades, various approaches have been explored to restore
sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new …
sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new …
[HTML][HTML] Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet–induced oxidative stress
T Abebe, J Mahadevan, L Bogachus, S Hahn, M Black… - JCI insight, 2017 - ncbi.nlm.nih.gov
Many theories have been advanced to better understand why β cell function and structure
relentlessly deteriorate during the course of type 2 diabetes (T2D). These theories include …
relentlessly deteriorate during the course of type 2 diabetes (T2D). These theories include …
Mutant mice with calcium-sensing receptor activation have hyperglycemia that is rectified by calcilytic therapy
VN Babinsky, FM Hannan, RD Ramracheya… - …, 2017 - academic.oup.com
The calcium-sensing receptor (CaSR) is a family C G-protein–coupled receptor that plays a
pivotal role in extracellular calcium homeostasis. The CaSR is also highly expressed in …
pivotal role in extracellular calcium homeostasis. The CaSR is also highly expressed in …