BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–
demand balance necessary for its contractile function in response to physiological …

Cell-based therapies represent a very promising strategy to repair and regenerate the
injured heart to prevent progression to heart failure. To date, these therapies have had …

Mitochondrial morphology is crucial for tissue homeostasis, but its role in cell differentiation
is unclear. We found that mitochondrial fusion was required for proper cardiomyocyte …

Cardiogenesis within embryos or associated with heart repair requires stem cell
differentiation into energetically competent, contracting cardiomyocytes. While it is widely …

Mitochondria are key players in the generation and regulation of cellular bioenergetics,
producing the majority of adenosine triphosphate molecules by the oxidative …

Cardiovascular diseases remain the leading cause of death worldwide; hence there is an
increasing focus on developing physiologically relevant in vitro cardiovascular tissue …

Oxidative phosphorylation (OXPHOS), the intracellular process that generates the majority of
the ATP of a cell through the electron-transfer chain, is highly dependent on proteins …

Pluripotent blastomeres of mammalian pre-implantation embryos and embryonic stem cells
(ESCs) are characterized by limited oxidative capacity and great reliance on anaerobic …

Mitochondrial biogenesis and activation of both oxidative phosphorylation, as well as
transcription and replication of the mitochondrial genome, are key regulatory events in cell …