Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

Hepatitis C virus (HCV) is a major global health burden with 2–3% of the world׳ s population
being chronically infected. Persistent infection can lead to cirrhosis and hepatocellular …

The mammalian cell membrane consists of thousands of different lipid species, and this
variety is critical for biological function. Alterations to this balance can be dangerous as they …

The hepatitis C virus (HCV) viroporin p7 oligomerizes to form ion channels, which are
required for the assembly and secretion of infectious viruses. The 63-amino acid p7 …

Protein p7 of HCV is a 63 amino acid channel forming membrane protein essential for the
progression of viral infection. With this momentousness, p7 emerges as an important target …

Background The current standard care therapy for hepatitis C virus (HCV) infection consists
of two regimes, namely interferon-based and interferon-free treatments. The treatment …

Viral proteins interact with lipid membranes during various stages in the viral life cycle to
propagate infection. p7 is an ion channel forming protein of Hepatitis C virus (HCV) that …

Viral proteins assemble into homopolymers in the infected cells and have a role as diffusion-
amplifier for ions across subcellular membranes. The homopolymer of hepatitis C virus …

Low-resolution models are often used to address macroscopic time and size scales in
molecular dynamics simulations of biomolecular systems. Coarse graining is often coupled …