Immunotherapies for hepatocellular carcinoma
JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Molecular and cellular mechanisms of liver fibrosis and its regression
T Kisseleva, D Brenner - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …
Immunological mechanisms and therapeutic targets of fatty liver diseases
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy
S Salman, DJ Meyers, EE Wicks… - The Journal of …, 2022 - Am Soc Clin Investig
Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and
available therapies, including immunotherapies, are ineffective for many patients. HCC is …
available therapies, including immunotherapies, are ineffective for many patients. HCC is …
Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease
S Zeng, E Rosati, C Saggau, B Messner, H Chu… - Cell host & …, 2023 - cell.com
Alcohol-associated liver disease is accompanied by intestinal mycobiome dysbiosis, yet the
impacts on liver disease are unclear. We demonstrate that Candida albicans-specific T …
impacts on liver disease are unclear. We demonstrate that Candida albicans-specific T …
Immunopathobiology and therapeutic targets related to cytokines in liver diseases
Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …
Interleukin-17 family members in health and disease
SH Chung, XQ Ye, Y Iwakura - International immunology, 2021 - academic.oup.com
Abstract The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and
all the corresponding receptors have been identified recently. This family is mainly involved …
all the corresponding receptors have been identified recently. This family is mainly involved …